Comments on the article of Bu, et al entitled "P16INK4a overexpression and survival in osteosarcoma patients: a meta analysis".

In the recent, with great interest we read the article “P16INK4a overexpression and survival in osteosarcoma patients: a meta analysis” (by Bu J et al). In this study, the investigators performed a meta-analysis to provide a comprehensive evaluation of the significance of P16INK4a expression in patients with osteosarcoma. This article showed that patients with high P16INK4a expression were significantly associated with favorable overall survival when compared to low or undetectable P16INK4a expression. The investigators concluded that P16INK4a is an effective biomarker of survival for osteosarcoma patients [1]. It is a valuable study. Nevertheless, there’re some flaws existing in this meta-analysis that we would like to raise.